![]() Meaningful percentages of cure or long-term remission from the disease must occur without significant nonhematopoietic toxicities that would otherwise limit the therapeutic benefit achieved.Īutologous transplants have also been used to reset the immune system in patients with severe autoimmune disorders.Ĭurrent pediatric indications for autologous transplant include patients with certain lymphomas, neuroblastoma, and brain tumors. ![]() This approach may include increased tumor kill in areas where standard-dose chemotherapy has less penetration (central nervous system). A dose-intensified chemotherapy regimen (with or without radiation therapy) with hematopoietic stem cell support is used to achieve a significantly higher cell kill than could be achieved without the use of hematopoietic stem cell support. ![]()
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